For those of us that need to haul around kids, dogs, gear (or just about anything from Costco) a bigger vehicle is always a necessity.  But with the prices of new full size SUV’s reaching new highs, there are reasons to look at used vehicles, and definitely specific things to look for when shopping for these land yachts.
First question you should attempt to answer is whether the vehicle in question has spent any time off the beaten path.  If the answer is a yes, then there will most certainly be more wear and tear on the suspension, engine, and transmission, among other things.  However, if you find a vehicle (or special edition of that vehicle) that was meant to go off-road, i.e. Z71 or TRD packages, you are probably ok as those were meant to take some abuse and keep on ticking.
The second question is whether there was any towing done in the vehicle’s past.  Often these family fortresses on wheels are used to pull the weekend camper, a boat, or even another car.  Towing greatly increases the stress on the drivetrain and can shorten the life of a vehicle pretty quickly if it wasn’t designed to tow any serious distances in the first place.  If the answer is yes, then check that the transmission fluid was changed regularly, closely inspect the rear suspension for sagging, and ask whether there is a transmission cooler installed.
Check the tires for even wear.  In connection with the potential towing and off-road shenanigans, tires do wear significantly faster when subjected to the more aggressive activities listed above.
Other than the above, the usual rules still apply when searching for a used SUV.  Don’t be afraid to ask about the history, talk to previous owners if possible, and take it for a long test drive.  Other than that, just be sure you are ready to take on the ownership of a full size SUV because bigger can often mean pricier.